Hexane extract of black cumin seeds ( Nigella sativa Lor ) was developed as a potential immunomodulator in patients with immunodeficiency such as HIV – AIDS infected patients who experienced a decrease in CD4 cell count, said Akrom Kes, lecturer at the Faculty of Pharmacy, University of Ahmad Dahlan Yogyakarta.
” Hexane extract of black cumin seeds ( EHBJH ) can be developed as a chemopreventive agent antikarsinogenesis through cytoprotective antioxidant and immunomodulatory mechanisms, ” he said in an open doctoral examination in the Faculty of Medicine, University of Gadjah Mada ( UGM) in Yogyakarta, on Monday ( 04/02/2013 ).
According to him, the effect EHBJH can increase CD4 lymphocytes, CD8, IFNgamma levels, and hematoprotektor. The success of black cumin seeds increase the number of CD4 and CD8 cells as well as the impact on CD4CD25Treg cell population gives hope to patients with HIV – AIDS undergoing antiretroviral therapy ( ARV ) as adjuvant therapy.
” Although the new scale laboratory research through the provision of hexane extract of black cumin seeds in mice, known to have timokuinon antikarsinogenesis chemopreventive effects in rats even able to reduce the mortality rate of 81-97 percent, inhibiting liver and kidney damage as well as increase the number of leukocytes and hemoglobin, ” he said.
He said, cumin seed hexane extract was also able to reduce the incidence of nodule formation 45-50 percent and 70-90 percent decrease formation of rat mammary adenocarcinoma induced dimetilbenz ( a) antracene.
In addition, the activity and immunomodulatory mechanisms antihematoksik hexane extract of black cumin seeds is known to increase the number of peripheral blood lymphocytes, increases the number of lymphocytes CD4Th, CD8 and CD4CD25treg, increase spleen weight and lymphocyte counts and lymphocyte activity in secreting IFNgamma.
According to him empirically black cumin seed has been used as a medicinal herb for the treatment of various disorders that are able to treat them as immunomodulatory, antiviral, antidiabetic mellitus, anticancer, antiasma, and antiepileptics.
” The content timokuinon, nigelon, and unsaturated fatty acids in the seeds of the black cumin is the content that is alleged antioxidative, chemopreventive, and immunomodulatory, ” said Akrom.