Albumin ( Latin: albus, white ) is the term used to refer to all types of protein monomers that are soluble in water or salt and suffer when exposed to heat coagulation. Substance containing albumin, such as egg whites, called albuminoid.
In humans, albumin produced by the endoplasmic reticulum in the liver in the form proalbumin, then sliced by a Golgi body secretes to meet around 60% of total blood serum concentrations between 30 and 50 g / L with a half time of about 20 days. Albumin has a molecular weight of approximately 65 kD and consists of 584 amino acids without carbohydrates. The gene for albumin is located on chromosome 4, with a length of about 16 961 nucleotides with 15 exons that are divided into the three domains of symmetrical, so estimated is triplikasi from a single primordial domain. Each domain is divided further into each sub- domain 2.
Mutations in this gene can result in a wide variety of proteins with functions that are not uniform ( English : anomalous protein) because of the changing nature of the domain source. Therefore, spesi reactive oxygen and nitrogen reactive spesi product of the reaction with other biomolecules such as lipid peroxidation products, physiology and pathophysiology occurring with the albumin.
- Preserving onkotik pressure. Onkotik pressure posed by albumin would preserve kidney function and reduce edema in the gastrointestinal tract, and used by hemodilution method to address acute stroke patients.
- Carrying the thyroid hormones
- Carrying other hormones, particularly fat-soluble
- Carried her toward the liver fatty acid
- Carrying drugs and drug cut the half time
- carrying bilirubin
- Binding Ca2 +
- As a buffer solution
- As an acute-phase inflammatory protein negative. Albumin concentration decreases as a sign of the acute phase immune response after an infection, but it does not mean that the body is in a state of nutritional deficiency
Albumin Health Benefits
It is produced by the liver. Because albumin is also used as a test assistant in the assessment of renal function and intestinal tract. If you experience any difficulty imagining the look of albumin, imagine the egg white.
Its molecular weight varies by species – consists of 584 amino acids. The protein is most abundant in eggs ( egg albumin ), blood ( serum albumin ), milk ( laktalbumin ). The molecular weight of 69,000 human plasma albumin, egg albumin 44,000, 63,000 mammal meat.
Albumin has a number of functions. First, as a carrier of small molecules through the plasma and liquid cells. This function is closely related to the metabolism of fatty – acid – free and bilirubuin and a variety of drugs that are less soluble in water and must be transported through the blood from one organ to another organ that can be metabolized or excreted. The second function that is the osmotic pressure in the capillaries.
Albumin useful in the formation of a new cell network. Therefore in medicine, albumin used to accelerate recovery of the torn tissue cells, such as operations, surgery, or burns. Other benefits, albumin can avoid causing swollen lungs and kidney failure as well as the carrier of blood clotting factors.
In short, albumin has a wide application and use in food or food and pharmaceutical products. In the food industry albumin products, among others, are useful in the manufacture of ice cream, porridge seniors, candy, bread, and pudding powder.
Whereas in the pharmaceutical, among others, used to shuffle ( whipping ), tension, or a tranquilizer and as an emulsifier. Albuminpun rates could decline due to medical factors, and this can be found in patients with chronic liver disease, kidney, intestinal tract, chronic and certain infections.